BAPTA-AM

O,O EBis(2-aminophenyl)ethyleneglycol-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester.


BAPTA is a calcium-selective chelator developed by Dr. Tsien. It has logKCa=6.97 and logKMg=1.77. The basic chelating unit resembles that of EGTA, but the two aliphatic nitrogen atoms are replaced by aromatic nitrogen. Thus, BAPTA is not protonated at physiological pH. BAPTA possesses pKa3=5.47 and pKa4=6.36. This property indicates that the deprotonation step is not included in its calcium complexation step, and it has a higher complexation rate than EGTA because it is not affected by proton interference.

BAPTA-AM
DJB018
25 mg