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GlykoPrep™ InstantPC, InstantAB and APTS kits for automation on the Agilent Bravo are now available! GlykoPrep™ with InstantPC labelling for MS applications. ProZyme, Inc. and BiOptic, Inc. Sign Licensing Agreement to Develop Gly-Q System for Glycan Analysis Development of an Instant Glycan Labeling Dye for High Throughput Analysis by Mass Spectrometry NEW PRODUCT: ProZyme launches improved 2-AB labeling kit NEW PRODUCT: ProZyme launches alpha(2-6)-Sialyltransferase kit NEW PRODUCT: ProZyme launches beta(1,4)-Galactosyltransferase kit NEW PRODUCT: Rapid-Reductive-Amination™ APTS Labeling now available for GlykoPrep™
Jun 04th, 2015

Development of an Instant Glycan Labeling Dye for High Throughput Analysis by Mass Spectrometry

Glycosylation of biotherapeutic proteins is frequently a critical quality attribute; therefore the characterization of glycans on biotherapeutics is an important activity in the development process. A common approach is to release and label N-glycans with a tag to allow for fluorescence detection; a process that often requires numerous hours to complete. Unfortunately, many of the most commonly used fluorescent tags have poor MS sensitivity.